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. 2022 Jan 18;12:747992. doi: 10.3389/fphar.2021.747992

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Copyright © 2022 Zeng, Xia, Zhao, Zhu, Zhang, Zhang, Rui, Li and Yuan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Anticancer efficacy on the subcutaneous tumor mouse model. (A) Flow chart of the experiment. (B) Representative tumor tissues excised from mice at the end of treatment. (C) Tumor weight at the end of treatment. (D) Body weight of tumor-bearing mice during the period of treatment. (E) Tumor volume with time after cancer cell inoculation. (F) Expression of Ki67 in cancer tissues, measured by IHC staining (scale bar: 100 μm). Data are expressed as mean ± SD (n = 6), **p < 0.01, ^a p < 0.01 Buf vs. PBS, ^b p < 0.05 MOF/Buf vs. Buf, ^c p < 0.05 FA-MOF/Buf vs. MOF/Buf.