Table 4.
Association of Donor UMOD to OPN ratio with Risk of All-Cause Graft Failure and Death-Censored Graft Failure in the Training and Test Data Set
| Ratio of UMOD to OPN | Total N | Mean Event Rate (95% CI), per 1000 person year | Unadjusted HR (95%CI) | Adjusteda HR (95% CI) | Mean Event Rate (95% CI), per 1000 person year | Unadjusted HR (95% CI) | Adjusteda HR (95% CI) |
|---|---|---|---|---|---|---|---|
| Training Data Set | |||||||
|
| |||||||
| Death Censored Graft Failure | All Cause Graft Failure (GF) | ||||||
|
| |||||||
| > 3 | 387 | 44.6 (35.0, 56.9) | 1 (ref) | 1 (ref) | 76.8 (63.9, 92.5) | 1 (ref) | 1 (ref) |
| ≤ 3 | 828 | 26.5 (21.5, 32.7) | 0.60 (0.43, 0.83) | 0.57 (0.41, 0.80) | 58.4 (50.7, 67.3) | 0.76 (0.60, 0.96) | 0.73 (0.57, 0.93) |
|
| |||||||
| Test Data Set | |||||||
|
| |||||||
| Death Censored Graft Failure | All Cause Graft Failure (GF) | ||||||
|
| |||||||
| > 3 | 385 | 43.1 (33.6, 55.1) | 1 (ref) | 1 (ref) | 85.4 (71.7, 101.8) | 1 (ref) | 1 (ref) |
| ≤ 3 | 830 | 29.9 (24.6, 36.5) | 0.69 (0.51, 0.96) | 0.73 (0.52, 1.02) | 59.3 (51.5, 68.2) | 0.69 (0.55, 0.87) | 0.70 (0.56, 0.88) |
Complete case analysis was completed since missing data was rare. Biomarker measurements and outcomes were available in all recipients. Covariate data was complete except for cold ischemia time (0.9% missing), HLA mismatch (0.2% missing) and BMI (0.04% missing).