TABLE 1.

Description of Simulations

	Site A		Site B		Site C
Experiment	Limited stage	Advanced stage	Limited stage	Advanced stage	Limited stage
Experiment 1 (virtual site), reference site = A	N = 1,000, μ = 8, SD = 3	ø	N = 1,000, μ = 12, SD = 4	ø	N = 1,000, μ = 14, SD = 5
Experiment 2, reference site = A	N = 1,000, μ = 8, SD = 3	N = 1,000, μ = 10, SD = 3	N = 1,000, μ = 12, SD = 4	N = 1,000, μ = 14, SD = 4	ø
Experiment 3, reference site = A, without and with covariate (=stage)	N = 1,000, μ = 8, SD = 3	N = 1,000, μ = 10, SD = 3	N = 1,000, μ = 12, SD = 4	ø	ø
Experiment 4, reference site = A, without and with covariate (=stage)	N = 1,000, μ = 8, SD = 3	N = 1,000, μ = 10, SD = 3	N = 200, μ = 12, SD = 4	N = 1,800, μ = 14, SD = 4	ø
Experiment 5, reference site = A, without and with covariate (=stage)	N = 1,000, μ = 8, SD = 3	N = 1,000, μ = 10, SD = 3	N = 1,000, μ = 12, SD = 4	N = 1,000, μ = 12, SD = 4	ø
Experiment 6, reference site = A, without and with covariate (=stage)	N = 1,000, μ = 8, SD = 3	N = 1,000, μ = 10, SD = 3	N = 1,000, μ = 12, SD = 4	N = 1,000, μ = 20, SD = 4	ø

N = number of simulated samples; μ = mean of gaussian distribution; ø = no simulation for this category.