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Summary of Results Obtained with ComBat to Adjust TMTV Cutoffs Between Different Sites
| Parameter | Cutoff | Youden | Sensitivity | Specificity |
|---|---|---|---|---|
| Cutoff optimized for M1 | 242 cm3 | 0.18 | 41% | 77% |
| Based on M1 cutoff, estimated cutoff for M2 (ComBat without log transformation) | 119 cm3 | 0.22 | 64% | 58% |
| Optimal cutoff for M2 | 112 cm3 | 0.23 | 66% | 57% |
