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. 2021 Dec 30;13(1):508–520. doi: 10.1080/21655979.2021.2009970

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Silencing of LCN2 restrains cell inflammation, oxidative stress and apoptosis in BEAS-2B cells by inactivating MAPK/ERK signaling pathway and diminishing ferroptosis. (a) Levels of TNF-α, IL-1β and IL-6 after transfection with sh-LCN2-2 with or without LM22B-10, detected by ELISA kits. (b) Levels of MDA, SOD, GSH and CAT after transfection with sh-LCN2-2 with or without LM22B-10, detected by commercial kits. (c,d) Cell apoptosis after transfection with sh-LCN2-2 with or without LM22B-10, detected by Tunel assay. E, Protein level of LCN2 after transfection with sh-LCN2-2 with or without LM22B-10, detected by Western BLOT analysis. Results are the mean ± SD. ***P < 0.001 versus control. ^###P < 0.001 versus LPS+sh-NC. ^ΔP < 0.05, ^ΔΔP < 0.01, ^ΔΔΔP < 0.001 versus LPS+sh-LCN2-2.