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. 2022 Jan 11;13(1):1359–1376. doi: 10.1080/21655979.2021.2017588

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — PI3K and NF-κB inhibition impaired the lncRNA PURPL-mediated cancer-promoting function The PI3K inhibitor LY294002 (Cat.No: HY-10108) (10 μM) and the NF-κB inhibitor JSH-23 (Cat.No: HY-13982) (30 μM) were administered to the AGS model with PURPL overexpression, respectively. A. Colony formation assay examined cell proliferation in each group. B. Transwell analyzed cell migration and invasion. C. Flow cytometry determined the apoptosis rate of AGS cells. D. Western blot confirmed the profiles of apoptosis-concerned cells Bax, Bcl2, and Caspase3. E. Western blot verified the protein profile of the PI3K/AKT/NF-κB pathway. **P < 0.01, ***, P < 0.001 (vs. the vec group), # P < 0.05, ## P < 0.01, ### P < 0.001 (vs. the PURPL group), N = 3.