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. 2022 Jan 3;13(1):810–823. doi: 10.1080/21655979.2021.2012952

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — The influence of miR-136-5p knockdown on silence of circPTK2-mediated CRC progression and chemoresistance. (a) miR-136-5p abundance was determined in HT-29 and LoVo cells with transfection of anti-miR-NC or anti-miR-136-5p. (b-o) HT-29 and LoVo cells were transfected with sh-circPTK2-1 and anti-miR-136-5p. Cell proliferation (b and c), colony formation (d and e), migration (f and g), invasion (h and i), 5-FU resistance (j and k), oxaliplatin resistance (l and m), β-catenin and cyclin D1 protein levels (n and o) were measured by CCK-8 assay, colony formation assay, transwell assay and WB analysis. *P < 0.05, **P < 0.01, ***P < 0.001.