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. 2022 Jan 3;13(1):974–984. doi: 10.1080/21655979.2021.2016038

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Knockdown of HOXA11-AS increased CDDP sensitivity of CDDP-resistant LSCC cells. (a) Reduced HOXA11-AS expression after transfection of shHOXA11-AS#1 and shHOXA11-AS#2 in TU686/CDDP and TU177/CDDP cells. (b and c) CCK-8 assay evaluated the cell proliferation of TU686/CDDP and TU177/CDDP cells transfected with shNC, shHOXA11-AS#1, and shHOXA11-AS#2. (c and d) The migration and invasion abilities of shNC, shHOXA11-AS#1 or shHOXA11-AS#1-transfected TU686/CDDP and TU177/CDDP cells were assessed via transwell assays. (e) The increased apoptosis rates of TU686/CDDP and TU177/CDDP cells transfected with shNC, shHOXA11-AS#1, and shHOXA11-AS#2 were detected through TUNEL assay. ** p < 0.01 and *** p < 0.001.