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. 2021 Dec 30;13(1):531–543. doi: 10.1080/21655979.2021.2009975

Figure 3.

Figure 3.

miR-200c antagomiR offset the effects of Magnolol on locomotor activity and cognitive function and levels of oxidative-related factors in AD model mice with brain insulin resistance. (a) The expressions of miR-200c in hippocampus tissues of the mice were quantified by RT-qPCR. U6 was used as an internal control. (b-c) OFT was performed to measure the locomotor ability of the mice. (d) NOR evaluation was employed to measure the discrimination ability of the mice. (e-g) MWM test was conducted to evaluate the spatial learning and memory ability of the mice. (h-j) The secretions of MDA (h), GSH (i), and SOD (j) in hippocampus tissues of the mice were detected by ELISA. (*P < 0.001, **P < 0.001, ***P < 0.001, vs. AntagomiR-NC; ^P < 0.05, ^^^P < 0.001, vs. AntagomiR; #P < 0.05, ##P < 0.01, ###P < 0.001, vs. AntagomiR-NC+ Magnolol 10; &P < 0.05, &&P < 0.01, &&&P < 0.001, vs. AntagomiR-NC+ Magnolol 15). (AD: Alzheimer’s disease, OFT: open-field test, NOR: novel object recognition, MWM: morris water maze, MDA: malondialdehyde, GSH: glutathione, SOD: superoxide dismutase, PCO: protein carbonylation).