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. 2021 Dec 30;13(1):531–543. doi: 10.1080/21655979.2021.2009975

Figure 4.

Figure 4.

miR-200c antagomiR offset the effect of Magnolol on the levels of inflammation-related factors in AD model mice with brain insulin resistance. (a-c) The secretions of TNF-α (a), IL-6 (b), and CRP (c) in hippocampus tissues of the mice were detected by ELISA. (d-e) The expressions of TNF-α, IL-6, and CRP in hippocampus tissues of the mice were detected by Western blot. GAPDH was used as an internal control. (*P < 0.001, ***P < 0.001, vs. AntagomiR-NC; ^^P < 0.05, ^^^P < 0.001, vs. AntagomiR; ##P < 0.01, ###P < 0.001, vs. AntagomiR-NC+ Magnolol 10; &&&P < 0.001, vs. AntagomiR-NC+ Magnolol 15). (AD: Alzheimer’s disease, TNF-α: tumor necrosis factor-α, IL-6: interleukin-6, CRP: C-reactive protein).