Figure 1.

Effects of germacrone on type I diabetic nephropathy (DN) symptoms. (a) Blood samples were collected from wild-type (WT), streptozocin (STZ)-induced mice. BG was determined using an Omron Glucometer, **P < 0.01. (b–f) Urine and blood samples of WT, STZ-induced mice and STZ+germacrone co-treated mice were collected. Subsequently, 24 h proteinuria, BUN, and BUA were analyzed using a fully automatic biochemical analyzer, and Ucr and Scr were measured with the homologous ELISA kits, **P < 0.01. (g–h) Kidney tissues obtained from the different groups were cut into paraffin sections. Then, the sections were stained by hematoxylin and eosin (HE) and PAS. Scale bar: 100 μm. Magnification: ×400, **P < 0.01. BG: blood glucose, Pro: proteinuria, BUN: blood urea nitrogen, Scr: serum creatinine, Ucr: urine creatinine, BUA: blood uric acid, Ger: Germacrone.