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Sitagliptin inhibited hypoxia-induced expressions of TNF-α, IL-6, and MCP-1. Cells were stimulated with Sitagliptin (100, 200 nM) for 2 hours, followed by exposure to hypoxia for 6 hours. (a). mRNA of TNF-α, IL-6, and MCP-1; (b). Protein levels of TNF-α, IL-6, and MCP-1 as measured by ELISA (****, P < 0.0001 vs. vehicle group; #, ##, P < 0.05, 0.01 vs. Sitagliptin group, n = 6).
