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Sitagliptin attenuated hypoxia-induced phosphorylation and degradation of IκBα. Cells were stimulated with Sitagliptin (100, 200 nM) for 2 hours, followed by exposure to hypoxia for 6 hours. p-IκBα and total IκBα (****, P < 0.0001 vs. vehicle group; #, ##, P < 0.05, 0.01 vs. Sitagliptin group, n = 5).
