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. 2021 Dec 30;13(1):455–468. doi: 10.1080/21655979.2021.2009410

Figure 1.

Figure 1.

Reversine suppressed breast cancer cells proliferation, migration and invasion while exacerbated their apoptosis in a dose-dependent manner. (a) The human breast cancer cell lines MDA-MB-231 and MCF-7 were treated with various dosages of reversine for 24 h and 48 h, and the CCK-8 assay was used to evaluate cell viability. (b) The cell viability of MDA-MB-231 and MCF-7 cell lines under the treatment of 0 μM, 0.15 μM and 0.3 μM reversine for 24 h, 48 h and 72 h was determined by CCK-8 assay. (c) BrdU assay indicated the cell proliferation of MDA-MB-231 and MCF-7 treated with 0 μM, 0.15 μM and 0.3 μM reversine for 48 h. (d) Apoptosis rate was examined in MDA-MB-231 and MCF-7 treated with 0 μM, 0.15 μM and 0.3 μM reversine for 48 h. (e) Wound healing assay showed cell migration ability of MDA-MB-231 and MCF-7 treated with 0 μM, 0.15 μM and 0.3 μM reversine for 48 h. (f) Transwell assay indicated cell invasion capacity of MDA-MB-231 and MCF-7 treated with 0 μM, 0.15 μM and 0.3 μM reversine for 48 h. * P < 0.05, ** P < 0.001 compared to 0 μM group.