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Blockage of AMPK abolishes the protective effects of Etomidate against IL-1β- induced cellular senescence. Cells were incubated with IL-1β (10 ng/mL) in the presence or absence of 6 μM Etomidate or the AMPK inhibitor compound C (10 μM). (a). mRNA levels of PAI-1 and p16; (b). Telomerase activity; (c). SA-β-Gal staining (###P < 0.005 vs. vehicle group; *, **P < 0.05, 0.01 vs. IL-1β group).
