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. 2022 Jan 4;13(1):1411–1423. doi: 10.1080/21655979.2021.2018096

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — CircZNF652 sponged miR-486-5p to modulate SERPINE1 expression in GBM cells. (a) and (b) The expression of miR-486-5p and SERPINE1 in GBM tissues and adjacent normal tissues. (c) and (d) The overall survival curve of high and low miR-486-5p and SERPINE1 expression GBM patients. (e) Spearman correlation analysis between circZNF652 and miR-486-5p expression, (f) between miR-486-5p and SERPINE1 expression, and (g) between circZNF652 and SERPINE1 expression in GBM tissues. (h)-(j) The mRNA and protein levels of SERPINE1 after A172 and U87 cells were transferred with si-NC or si-circZNF652. (k) and (l) The expression of cirZNF652 was calculated by RT-qPCR after A172 and U87 cells were transferred with NC mimic, miR-486-5p mimic, miR-486-5p mimic+pcDNA3.1, miR-486-5p mimic+pcDNA-SERPINE1. ***P < 0.001.