Table 1.
Study characteristics
| Type of study | Study | Sample size | Patient age (mean) | CDI severity | F/U duration (weeks) | FMT administration | Amount of fecal material delivered per FMT | Average # of FMT needed to treat | FMT regimen PMC driven (12) | Antibiotic usage* | # of patients achieving overall cure from FMT | Time to discharge after final FMT therapy (Weeks) | NIH Score for Case series or RCTs |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case Series | Weingarden (11) | 4 | 72.75 | SFCDI | 27 | Lower endoscopy | N/A | 1.6 | No | Physician’s discretion | 2/4 | 3.5 | 7 |
| Gundacker (26) | 8 | 68 | SFCDI | 65.7 | Upper GI + lower endoscopy + enema | 30g | 1.5 | No | Physician’s discretion | 6/8 | unclear | 8 | |
| Alukal (27) | 9 | 67.78 | F | 16 | Upper GI + lower endoscopy + enema | 50g | 1 | No | Physician’s discretion | 8/9 | 20.78 | 8 | |
| Kelly (10) | 11 | 67 | SFCDI | 12 | Upper GI + lower endoscopy | N/A | 1.45 | No | Physician’s discretion | 10/11 | unclear | 8 | |
| Zainah (28) | 14 | 73.4 | S | 14.3 | Upper GI + lower endoscopy | 30-50g | 1.43 | No | Physician’s discretion | 11/14 | unclear | 6 | |
| Aroniadis (29) | 17 | 66 | SFCDI | 45.6 | Upper GI + lower endoscopy + enema | N/A | unclear | No | Physician’s discretion | 15/17 | unclear | 5 | |
| Ianiro (30) | 48 | 74.87 | SFCDI | 63.7 | Lower endoscopy | ≥50g | 2.08 | No | Physician’s discretion | 45/48 | 6.18 | 9 | |
| Fischer (19) | 57 | 72 | SFCDI | 12 | Lower endoscopy | 50-200g | 1.6 | Yes | Part of protocol | 52/57 | 11 | 9 | |
| Case control | Tixier (25) | 16 | 62.9 | SFCDI | 30 | Lower endoscopy | N/A | 1.4 | Yes | Part of protocol | 13/16 | unclear | 8 |
| Randomized Trial | Ianiro (14) | 56 | 74.5 | SFCDI | 8 | Lower endoscopy | ≥50g | 2.25 | Yes | Part of protocol | 49/56 | unclear | 10 |
*More details are given in Supplementary Table 5.