Table 3:

MCI

	Memory			EF
Category	Beta	F-value	p-value	Beta	F-value	p-value
Age	−0.008	3.222	0.074	−0.027	15.372	<0.001
Gender	−0.215	12.227	0.001	−0.104	1.341	0.248
Education	0.076	4.805	0.029	0.132	4.757	0.030
Pathology Composite	−1.244	156.122	<0.001	−0.789	58.864	<0.001
Time	−0.107	18.210	<0.001	−0.072	1.918	0.127
Path Composite × Time	−0.538	13.794	<0.001	−0.357	5.692	0.001
Education × Path	0.053	0.070	0.792	−0.151	3.753	0.054
Education × Time	0.006	0.158	0.924	−0.076	1.376	0.250
Education x Path x Time	−0.122	1.236	0.297	−0.176	0.960	0.412

Unstandardized beta, F and p values are reported for linear mixed models for both MEM and EF in those with MCI. There were no education x pathology x time interactions through 2 years, although there was a trend for an education x pathology interaction at baseline for EF. However, in this interaction EF scores were not as negatively affected by pathology in lower education than those with higher education, which the opposite direction expected using cognitive reserve theory.