Skip to main content
. 2022 Feb 1;19(2):e1003679. doi: 10.1371/journal.pmed.1003679

Fig 5. Clustering of the genetic effect of obesity on female reproductive disorders.

Fig 5

(A) Female reproductive disorders separated by the genetic effects of different obesity traits on reproductive conditions. Uniform Manifold Approximation and Projection (UMAP) was used to plot the separation of diseases based on genetic effects of obesity instruments, evaluated by 2-sample Mendelian randomisation. (B) Number of SNPs in substantial clusters for each obesity × female reproductive condition relationship. SNPs with ≥80% probability of belonging to a substantial cluster (MRClust) are displayed with their nearest gene as annotated by SNPsnap and ‘+’ or ‘−’ representing causal effect direction. BMI, body mass index; Endo, endometriosis; HMB, heavy menstrual bleeding; Infert., infertility; M. misc., multiple consecutive miscarriage; PCOS, polycystic ovary syndrome; PE, pre-eclampsia; S. misc., sporadic miscarriage; UF, uterine fibroids; WHR, waist-to-hip ratio; WHRadjBMI, waist-to-hip ratio adjusted for BMI.