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. 2021 Nov;32(11):2743–2758. doi: 10.1681/ASN.2021040433

Table 1.

Top 30 redundant transcripts associated with known DSA status in a t test in the n=1679 populationa

Adjusted P Value Gene Symbol Gene Name Transcript Set Annotation Transcript Expression in All Biopsy Samples
n=1679		 Transcript Expression in NR Biopsy Samples
n=1012
DSA+
(n=576)		 DSA−
(n=818)		 DSA+
(n=271)		 DSA−
(n=564)
<0.001 ROBO4 Roundabout, axon guidance receptor, homolog 4 (Drosophila) ABMR-RAT 747b 590 617b 580
<0.001 SH2D1B SH2 domain containing 1B ABMR-RAT 18b 13 13b 12
<0.001 PLA1A Phospholipase A1 member A ABMR-RAT, GRIT 386b 268 242b 224
<0.001 SH2D1B SH2 domain containing 1B ABMR-RAT 32b 24 23b 22
<0.001 S1PR5 Sphingosine-1-phosphate receptor 5 ABMR-RAT 23b 20 19b 19
<0.001 CX3CL1 Chemokine (C-X3-C motif) ligand 1 ABMR-RAT 641b 539 548b 510
<0.001 ROBO4 Roundabout, axon guidance receptor, homolog 4 (Drosophila) ABMR-RAT 510b 434 449b 433
<0.001 TRDC T cell receptor δ constant ABMR-RAT 76b 62 64b 61
<0.001 LYPD5 LY6 ABMR-RAT 22b 17 16b 15
<0.001 COL13A1 collagen, type XIII, alpha 1 ABMR-RAT 45b 36 38b 37
<0.001 LYPD5 LY6 ABMR-RAT 17b 14 13b 13
<0.001 TRDC T cell receptor δ constant ABMR-RAT 87b 60 55b 50
<0.001 TRDC T cell receptor δ constant ABMR-RAT 80b 49 44b 37
<0.001 CXCL11 Chemokine (C-X-C motif) ligand 11 ABMR-RAT, GRIT 225b 99 80b 54
<0.001 COL13A1 Collagen, type XIII, alpha 1 ABMR-RAT 57b 50 52b 51
<0.001 CXCL11 Chemokine (C-X-C motif) ligand 11 ABMR-RAT, GRIT 104b 46 37b 24
<0.001 CCL4L1 Chemokine (C-C motif) ligand 4-like 1 ABMR-RAT 56b 34 31b 27
<0.001 FGFBP2 Fibroblast growth factor binding protein 2 ABMR-RAT 64b 46 40b 37
<0.001 CXCL11 Chemokine (C-X-C motif) ligand 11 ABMR-RAT, GRIT 69b 31 25b 17
<0.001 SH2D1B SH2 domain containing 1B ABMR-RAT 36b 29 28b 27
<0.001 KLRF1 Killer cell lectin-like receptor subfamily F, member 1 ABMR-RAT 78b 59 56b 52
<0.001 CCL4 Chemokine (C-C motif) ligand 4 ABMR-RAT 162b 95 83b 67
<0.001 CD160 CD160 molecule ABMR-RAT 40b 29 26b 25
<0.001 ROBO4 Roundabout, axon guidance receptor, homolog 4 (Drosophila) ABMR-RAT 153b 132 139b 136
<0.001 TRDV3 T cell receptor δ variable 3 ABMR-RAT 21b 15 13b 12
<0.001 NCR1 Natural cytotoxicity triggering receptor 1 ABMR-RAT 12b 10 9 9
<0.001 GNLY Granulysin ABMR-RAT 107b 89 84b 79
<0.001 GNLY Granulysin ABMR-RAT 96b 61 51b 45
<0.001 GNLY Granulysin ABMR-RAT 101b 67 56b 50
<0.001 GBP4 Guanylate binding protein 4 ABMR-RAT, GRIT 168b 112 100b 86

ABMR-RAT, ABMR-associated transcripts; GRIT, γ-interferon–inducible transcripts.

a

Total population of 1679, with 285 biopsy samples with missing DSA status, 1394 included in the analysis.

b

Highest expression in DSA+ versus DSA− within each category (n=1679 and n=1012).