The relationship of histologic alterations and kidney function stratified by HTN and diabetes. (A–C) Adjusted means for percent IF, TA, and GS stratified by absence of HTN and DM (n=193, navy lines±shaded 95% CI and navy bars), HTN alone (n=290, light blue lines±shaded 95% CI and light blue bars), and presence of HTN and DM (n=238, orange lines±shaded 95% CI shaded and orange bars). Percentages of IF, TA, and GS modeled using linear regression as a cubic function of eGFR3 adjusted for age, sex, race, HTN, diabetes, and BMI. Asterisk denotes P<0.05 compared with the “No HTN or DM” group, **P<0.01, * <0.05.