Table 4.
Clinical and histopathological variables associated with kidney function decline: Variables (fixed effects) associated with eGFR decline in linear mixed model
| Longitudinal eGFR (n=167) | Coefficient | SE | z | P>|z| | 95% Confidence Interval | |
|---|---|---|---|---|---|---|
| Age (per 1 year older) | −0.25 | 0.06 | −4.21 | <0.001 | −0.36 | −0.13 |
| eGFR baseline (per 1 ml/min per 1.73 m2) | 0.74 | 0.03 | 25.18 | <0.001 | 0.68 | 0.80 |
| GS (per 1% difference) | −0.25 | 0.06 | −4.35 | <0.001 | −0.36 | −0.14 |
| Radical nephrectomy (yes/no) | −4.32 | 1.40 | −3.10 | <0.01 | −7.05 | −1.58 |
| Tumor size (per 1 cm difference) | −0.01 | 0.20 | −0.03 | 0.98 | −0.39 | 0.38 |
| Sex, F (yes/no) | −1.68 | 1.34 | −1.26 | 0.21 | −4.30 | 0.94 |
| Race, Black (yes/no) | −2.64 | 1.96 | −1.35 | 0.18 | −6.49 | 1.20 |
| BMI (per 1 kg/m2) | −0.04 | 0.08 | 0.47 | 0.66 | −0.20 | 0.13 |
| Diabetes (yes/no) | 0.59 | 1.26 | 0.52 | 0.64 | −1.87 | 3.06 |
| HTN (yes/no) | −0.43 | 1.48 | −0.29 | 0.77 | −3.33 | 2.48 |
| Length of follow-up time (per 1 year difference) | −0.02 | 0.12 | −0.14 | 0.89 | −0.26 | 0.22 |
Variables meeting significance (P<0.05) shown in bold. Coefficients represent fixed effects obtained in linear mixed model using subject-specific eGFR slopes obtained by regressing repeated eGFR values on the time variable (random effects). F, female.