Table 2.
Network performance
| Species | Podocyte Marker | Dataset | pix2pix | CNN | ||
|---|---|---|---|---|---|---|
| Ctrl. | Dis. | Ctrl. | Dis. | |||
| Mouse | WT1 | STZ-model | 0.83/0.85 | 0.90/0.82 | 0.73/0.8 | 0.83/0.79 |
| Mouse | p57 | NTN-model | 0.35/0.87 | 0.31/0.91 | 0.94/0.73 | 0.71/0.86 |
| Rat | WT1 | PAN-model | 0.75/0.82 | 0.80/0.80 | 0.80/0.85 | 0.80/0.79 |
| Rat | p57 | PAN-model | 0.80/0.83 | 0.83/0.82 | 0.83/0.90 | 0.80/0.87 |
| Human | WT1 | Autopsy sections | 0.67/0.80 | 0.85/0.85 | ||
| Human | p57 | Autopsy sections | 0.75/0.91 | 0.75/0.94 | ||
| Human | WT1 | Biopsy sections | 0.42/0.89 | 0.75/0.97 | ||
| Human | p57 | Biopsy sections | 0.83/0.92 | 0.86/0.94 | ||
Performance of the networks for individual datasets compared with the IF/IHC ground-truth. Network performance (sensitivity/specificity) was calculated by comparing the network-estimated podocytes with the ground-truth podocytes extracted from the IF/IHC images via morphologic processing. Ctrl., control; Dis., disease; NTN, nephrotoxic nephritis.