Table 4.
Multivariable risk of proteinuria: Cox regression
| Variable | Model 1 (n=7029) | Model 2 (n=7068) | ||
|---|---|---|---|---|
| aHR (95% CI) | P Value | aHR (95% CI) | P Value | |
| Age (years) | 1.01 (1.01, 1.02) | <0.001 | 1.01 (1.01, 1.02) | <0.001 |
| Male | 0.87 (0.75, 1.02) | 0.09 | 0.88 (0.76, 1.03) | 0.11 |
| Not non-Hispanic White | 1.18 (0.95, 1.45) | 0.13 | 1.18 (0.95, 1.45) | 0.13 |
| Related to the recipient | 0.53 (0.45, 0.62) | <0.001 | 0.54 (0.46, 0.63) | <0.001 |
| BMI (kg/m2) | ||||
| <30 | (reference) | (reference) | ||
| 30–34.9 | 1.56 (1.32, 1.85) | <0.001 | 1.62 (1.37, 1.90) | <0.001 |
| ≥35 | 2.04 (1.63, 2.56) | <0.001 | 2.06 (1.65, 2.58) | <0.001 |
| Systolic BP (mmHg) | 1.01 (1.00, 1.02) | 0.002 | 1.01 (1.01, 1.02) | 0.001 |
| Diastolic BP (mmHg) | 0.99 (0.97, 1.00) | 0.01 | 0.98 (0.97, 1.00) | 0.004 |
| Fasting glucose (mg/dl) | 1.00 (1.00, 1.01) | 0.21 | 1.00 (1.00, 1.01) | 0.07 |
| Serum creatinine (mg/dl) | 3.59 (2.52, 5.13) | <0.001 | 3.50 (2.46, 4.99) | <0.001 |
| Smoking | 0.96 (0.85, 1.09) | 0.55 | 0.98 (0.86, 1.11) | 0.74 |
| Hyperlipidemia | 1.61 (1.41, 1.85) | <0.001 | 1.64 (1.43, 1.88) | <0.001 |
| Postdonation diabetes | 1.02 (1.01, 1.03) | 0.001 | – | – |
| Postdonation hypertension | 1.01 (0.99, 1.02) | 0.35 | – | – |
Model 1: Adjusted for postdonation diabetes and hypertension as time-dependent covariates; Model 2: Not adjusted for postdonation diabetes and hypertension.