Table 5.
Multivariable risk of eGFR <60, eGFR <45, and eGFR <30 ml/min per 1.73m2: Cox regression
| Variable | Model 1 (n=7089) | Model 2 (n=7684) | ||
|---|---|---|---|---|
| aHR (95% CI) | P Value | aHR (95% CI) | P Value | |
| eGFR<60 ml/min per 1.73m2 | ||||
| Related to the recipient | 0.68 (0.64, 0.73) | <0.001 | 0.70 (0.65, 0.74) | <0.001 |
| BMI (kg/m2) | ||||
| <30 | (reference) | (reference) | ||
| 30–34.9 | 1.31 (1.21, 1.41) | <0.001 | 1.29 (1.20, 1.39) | <0.001 |
| ≥35 | 1.13 (0.99, 1.29) | 0.07 | 1.12 (0.98, 1.27) | 0.09 |
| Systolic BP (mmHg) | 1.01 (1.01, 1.01) | <0.001 | 1.01 (1.01, 1.01) | <0.001 |
| Fasting glucose (mg/dl) | 1.01 (1.01, 1.01) | <0.001 | 1.01 (1.01, 1.01) | <0.001 |
| Postdonation diabetes | 0.99 (0.98, 1.00) | 0.13 | – | – |
| Postdonation hypertension | 0.99 (0.99, 1.00) | 0.09 | – | – |
| eGFR<45 ml/min per 1.73m2 | ||||
| Related to the recipient | 0.67 (0.56, 0.79) | <0.001 | 0.70 (0.59, 0.82) | <0.001 |
| BMI (kg/m2) | ||||
| <30 | (reference) | (reference) | ||
| 30–34.9 | 1.56 (1.32, 1.84) | <0.001 | 1.54 (1.31, 1.81) | <0.001 |
| ≥35 | 1.28 (0.97, 1.70) | 0.09 | 1.22 (0.93, 1.61) | 0.16 |
| Systolic BP (mmHg) | 1.02 (1.01, 1.03) | <0.001 | 1.02 (1.02, 1.03) | <0.001 |
| Fasting glucose (mg/dl) | 1.01 (1.01, 1.02) | <0.001 | 1.01 (1.01, 1.02) | <0.001 |
| Postdonation diabetes | 1.00 (0.99, 1.01) | 0.97 | – | – |
| Postdonation hypertension | 1.01 (1.00, 1.03) | 0.13 | – | – |
| eGFR<30 ml/min per 1.73m2 | ||||
| Related to the recipient | 3.12 (0.41, 23.53) | 0.27 | 3.34 (0.45, 24.87) | 0.24 |
| BMI (kg/m2) | ||||
| <30 | (reference) | (reference) | ||
| 30–34.9 | 2.61 (1.28, 5.30) | 0.01 | 2.51 (1.24, 5.08) | 0.01 |
| ≥35 | 2.48 (0.87, 7.07) | 0.09 | 2.24 (0.79, 6.36) | 0.13 |
| Systolic BP (mmHg) | 1.03 (1.00, 1.05) | 0.04 | 0.00 (0.00, 0.00) | |
| Fasting glucose (mg/dl) | 1.02 (1.00, 1.04) | 0.03 | 1.04 (1.01, 1.06) | 0.002 |
| Postdonation diabetes | 1.02 (0.99, 1.05) | 0.24 | 1.02 (1.00, 1.04) | 0.01 |
| Postdonation hypertension | 1.03 (0.99, 1.08) | 0.18 | – | – |
Model 1: Adjusted for postdonation diabetes and hypertension as time-dependent covariates; Model 2: Not adjusted for postdonation diabetes and hypertension.