Table 8.
Multivariable risk of mortality: Cox regression
| Variable | Model 1 | Model 2 | ||
|---|---|---|---|---|
| aHR (95% CI) | P Value | aHR (95% CI) | P Value | |
| Adjusted for the time-varying postdonation ESKD | (n=7187) | (n=7846) | ||
| Age (yrs) | 1.12 (1.10, 1.14) | <0.001 | 1.09 (1.08, 1.10) | <0.001 |
| Male | 1.90 (1.38, 2.62) | <0.001 | 1.87 (1.45, 2.42) | <0.001 |
| Not non-Hispanic White | 1.87 (1.14, 3.06) | 0.01 | 1.65 (1.11, 2.46) | 0.01 |
| Related to the recipient | 0.83 (0.41, 1.68) | 0.61 | 0.89 (0.51, 1.56) | 0.69 |
| BMI (kg/m2) | ||||
| <30 | (reference) | (reference) | ||
| 30–34.9 | 1.04 (0.65, 1.67) | 0.86 | 0.84 (0.57, 1.23) | 0.37 |
| ≥35 | 1.64 (0.74, 3.65) | 0.23 | 1.54 (0.81, 2.94) | 0.19 |
| Systolic BP (mmHg) | 1.01 (0.99, 1.02) | 0.31 | 1.00 (0.99, 1.01) | 0.67 |
| Diastolic BP (mmHg) | 1.01 (0.99, 1.04) | 0.36 | 1.00 (0.98, 1.02) | 0.92 |
| Fasting glucose (mg/dl) | 1.01 (1.00, 1.01) | 0.23 | 1.00 (1.00, 1.01) | 0.23 |
| Serum creatinine (mg/dl) | 0.20 (0.08, 0.49) | <0.001 | 0.30 (0.14, 0.63) | 0.001 |
| Smoking | 1.90 (1.41, 2.55) | <0.001 | 1.96 (1.57, 2.44) | <0.001 |
| Hyperlipidemia | 1.25 (0.92, 1.70) | 0.15 | 1.26 (1.01, 1.57) | 0.04 |
| Postdonation diabetes | 1.00 (0.98, 1.02) | 0.92 | – | – |
| Postdonation hypertension | 0.97 (0.96, 0.98) | <0.001 | – | – |
| Postdonation ESKD | 1.01 (0.98, 1.05) | 0.49 | – | – |
| Adjusted for obesity/ESKD status | ||||
| Age (yrs) | 1.12 (1.10, 1.14) | <0.001 | – | – |
| Male | 1.88 (1.36, 2.60) | <0.001 | – | – |
| Not non-Hispanic White | 1.89 (1.15, 3.11) | 0.01 | – | – |
| Related to the recipient | 0.84 (0.42, 1.69) | 0.62 | – | – |
| Systolic BP (mmHg) | 1.01 (0.99, 1.02) | 0.28 | – | – |
| Diastolic BP (mmHg) | 1.01 (0.99, 1.04) | 0.35 | – | – |
| Fasting glucose (mg/dl) | 1.01 (1.00, 1.01) | 0.27 | – | – |
| Serum creatinine (mg/dl) | 0.20 (0.08, 0.48) | <0.001 | – | – |
| Smoking | 1.91 (1.42, 2.57) | <0.001 | – | – |
| Hyperlipidemia | 1.27 (0.93, 1.74) | 0.13 | – | – |
| Postdonation diabetes | 1.00 (0.98, 1.02) | 0.89 | – | – |
| Postdonation hypertension | 0.97 (0.96, 0.98) | <0.001 | – | – |
| Obesity/ESKD subgroup | – | – | ||
| Nonobese/no ESKD postdonation | (reference) | – | – | |
| Obese/no ESKD postdonation | 1.00 (0.98, 1.02) | 0.84 | – | – |
| Nonobese/ESKD postdonation | 1.01 (0.98, 1.04) | 0.59 | – | – |
| Obese/ESKD postdonation | 1.05 (0.92, 1.20) | 0.47 | – | – |
Model 1: Adjusted for postdonation diabetes and hypertension as time-dependent covariates; Model 2: Not adjusted for postdonation diabetes and hypertension.