Table 9.
Overall multivariable risk of death, CVD, eGFR outcomes and ESKD
| Outcome | BMI 30–34.9 Versus BMI <30 | BMI≥35 Versus BMI <30 | ||||||
|---|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 1 | Model 2 | |||||
| aHR (95% CI) | P Value | aHR (95% CI) | P Value | aHR (95% CI) | P Value | aHR (95% CI) | P Value | |
| Categorical BMI | ||||||||
| Death (n=418/n=8583) | 1.04 (0.65, 1.67) | 0.86 | 0.84 (0.57, 1.23) | 0.37 | 1.64 (0.74, 3.65) | 0.23 | 1.54 (0.81, 2.94) | 0.19 |
| CVD (n=1085/n=8569) | 1.22 (0.93, 1.60) | 0.15 | 1.32 (1.09, 1.59) | 0.004 | 1.80 (1.24, 2.61) | 0.002 | 1.51 (1.12, 2.03) | 0.01 |
| Diabetes (n=566/n=7879) | 2.01 (1.45, 2.78) | <0.001 | 2.07 (1.49, 2.86) | <0.001 | 3.51 (2.28, 5.42) | <0.001 | 3.52 (2.28, 5.43) | <0.001 |
| Hypertension (n=2298/n=7696) | 1.50 (1.32, 1.70) | <0.001 | 1.50 (1.33, 1.70) | <0.001 | 1.55 (1.29, 1.87) | <0.001 | 1.53 (1.27, 1.85) | <0.001 |
| Proteinuria (n=1073/n=7687) | 1.56 (1.32, 1.85) | <0.001 | 1.62 (1.37, 1.90) | <0.001 | 2.04 (1.63, 2.56) | <0.001 | 2.06 (1.65, 2.58) | <0.001 |
| eGFR <60 (n=4655/n=8374) | 1.31 (1.21, 1.41) | <0.001 | 1.29 (1.20, 1.39) | <0.001 | 1.13 (0.99, 1.29) | 0.07 | 1.12 (0.98, 1.27) | 0.09 |
| eGFR <45 (n=1011/n=8374) | 1.56 (1.32, 1.84) | <0.001 | 1.54 (1.31, 1.81) | <0.001 | 1.28 (0.97, 1.70) | 0.09 | 1.22 (0.93, 1.61) | 0.16 |
| eGFR <30 (n=59/n=8374) | 2.61 (1.28, 5.30) | 0.01 | 2.51 (1.24, 5.08) | 0.01 | 2.48 (0.87, 7.07) | 0.09 | 2.24 (0.79, 6.36) | 0.13 |
| ESKD (n=43/n=8016) | 1.90 (0.77, 4.64) | 0.16 | 2.30 (1.03, 5.14) | 0.04 | 3.21 (0.87, 11.81) | 0.08 | 4.29 (1.39, 13.20) | 0.01 |
| Composite of eGFR<30 or ESKD (n=85/n=8552) | 2.22 (1.19, 4.15) | 0.01 | 2.16 (1.18, 3.93) | 0.01 | 2.72 (1.16, 6.36) | 0.02 | 2.70 (1.21, 6.05) | 0.02 |
| Model 1 | Model 2 | |||
|---|---|---|---|---|
| aHR (95% CI) | P Value | aHR (95% CI) | P Value | |
| Continuous BMI | ||||
| Death (n=418/n=8583) | 1.02 (0.98, 1.07) | 0.28 | 1.01 (0.98, 1.04) | 0.65 |
| CVD (n=1085/n=8569) | 1.03 (1.01, 1.06) | 0.002 | 1.03 (1.01, 1.05) | <0.001 |
| Diabetes (n=566/n=7879) | 1.11 (1.08, 1.13) | <0.001 | 1.11 (1.09, 1.13) | <0.001 |
| Hypertension (n=2298/n=7696) | 1.05 (1.04, 1.06) | <0.001 | 1.05 (1.04, 1.06) | <0.001 |
| Proteinuria (n=1073/n=7687) | 1.05 (1.04, 1.07) | <0.001 | 1.05 (1.04, 1.07) | <0.001 |
| eGFR <60 (n=4655/n=8374) | 1.03 (1.02, 1.04) | <0.001 | 1.03 (1.02, 1.04) | <0.001 |
| eGFR <45 (n=1011/n=8374) | 1.05 (1.03, 1.06) | <0.001 | 1.05 (1.03, 1.06) | <0.001 |
| eGFR <30 (n=59/n=8374) | 1.07 (1.01, 1.13) | 0.02 | 1.08 (1.02, 1.14) | 0.01 |
| ESKD (n=43/n=8016) | 1.08 (1.02, 1.15) | 0.01 | 1.12 (1.07, 1.18) | <0.001 |
| Composite of eGFR<30 or ESKD (n=85/n=8552) | 1.08 (1.03, 1.13) | 0.003 | 1.09 (1.04, 1.14) | <0.001 |
n, number of outcome events; N, total number of donors with ascertained outcome status; Model 1: Adjusted for postdonation diabetes, hypertension, and ESKD as time-dependent covariate; Model 2: Not adjusted for postdonation diabetes, hypertension and ESKD.