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. 2021 Nov;32(11):2777–2794. doi: 10.1681/ASN.2020121699

Figure 1.

Figure 1.

Glomerular miR-192-5p is upregulated in patients with iMGN. (A) Quantitative PCR (qPCR) for miR-378a-3p and miR-192-5p in 10 healthy controls (CTRL) and 20 patients with iMGN. Data were normalized to spiked-in cel-miR39. *P<0.05, **P<0.01. (B) Left: In situ hybridization for miR-192-5p on a representative kidney biopsy from patients with iMGN and CTRL. Scale bar=50 µm. Right: Quantification of relative glomerular miR-192-5p expression of kidney biopsies from patients with iMGN compared with CTRL. *P<0.05. n=10 patients and three controls, three glomeruli of each were analyzed. (C) Left: In situ hybridization for miR-378a-3p on a representative kidney biopsy from patients with iMGN and CTRL. Scale bar=50 µm. Right: Quantification of relative glomerular miR-378a-3p expression of kidney biopsies from patients with iMGN compared with CTRL. *P<0.05. n=10 patients and three controls, three glomeruli of each were analyzed.