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. 2021 Aug 28;15(9):687–697. doi: 10.1049/nbt2.12067

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© 2021 The Authors. IET Nanobiotechnology published by John Wiley & Sons Ltd on behalf of The Institution of Engineering and Technology.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Secondary identification and functional analysis of differential metabolites. (a) Secondary identification of differential metabolites following a 24 h zirconium oxide nanoparticle (ZrO₂ NP) treatment; (b) Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of differential metabolites following a 24 h ZrO₂ NP treatment; (c) Secondary identification of differential metabolites following a 48 h ZrO₂ NP treatment; (d) KEGG pathway analysis of differential metabolites following a 48 h ZrO₂ NP treatment