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. 2022 Jan 18;12:794620. doi: 10.3389/fphar.2021.794620

FIGURE 5.

FIGURE 5

Mean effects of different IK1 formulation on guinea-pig ventricular action potential parameters. (A). Mean (±SEM) of APD90 values for APs elicited at 1 Hz for WT, WT-D172N and D172N IK1 conditions. (B). Mean (±SEM) APD90-APD30 values (as an index of AP triangulation) for WT, WT-D172N and D172N IK1 conditions. (C). Mean (±SEM) maximal upstroke velocity (Vmax) values for WT, WT-D172N and D172N IK1 conditions. (D). Mean (±SEM) maximal repolarization velocity values for WT, WT-D172N and D172N IK1 conditions. “*” denotes statistical significance of p < 0.05; “**” denotes statistical significance of p < 0.01; “***” denotes statistical significance of p < 0.001 (one-way ANOVA test, followed by Tukey’s multiple comparisons test; n = 5 cells from 4 hearts to which all IK1 formulations were applied).