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. 2021 May 4;12(1):1505–1516. doi: 10.1080/21655979.2021.1916271

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Cisatracurium inhibits the expression of miR-181b by activating lincRNA-p21. (a) miR-181b expression in OVCAR-3 cells transfected with Ov-p53 or shRNA-p53 was detected by real-time PCR. *p < 0.05 and ***p < 0.001 vs. Control; ^∆p < 0.05 vs. shRNA-NC. (b) Knockdown efficiency of lincRNA-p21 expression was detected by real-time PCR. ***p < 0.001 vs. Control. (c) Overexpressed efficiency of lincRNA-p21 expression was detected by real-time PCR. ***p < 0.001 vs. Control. (d) miR-181b expression in OVCAR-3 cells transfected with shRNA-LINC-P21 or Ov-LINC-P21 was detected by real-time PCR. ***p < 0.001 vs. Control; ^###p < 0.001 vs. shRNA-NC; ^∆∆∆p < 0.001 vs. Ov-NC. (e) Effect of lincRNA-p21 on miR-181b expression was determined by real-time PCR. **p < 0.001 vs. 20 μM+sh-NC. (f) Overexpression efficiency of miR-181b expression was detected by real-time PCR. ^###p < 0.001 vs. miR-NC. (g) Predicted binding sites for miR-181b in lincRNA-p21. (h) The relationship between lincRNA-p21 and miR-181b was determined by luciferase reporter assay in OVCAR-3 cells. n = 3