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The schematic diagram of the action of MIR205HG in OS. In normal cells, miR-2114-3p binds to TWIST2 mRNA 3`-UTR, resulting in decreased TWIST2 level; In OS cells, MIR205HG sponges miR-2114-3p, antagonizing the inhibitory effect of miR-2114-3p on TWIST2, thereby increasing TWIST2 expression and subsequently promoting OS metastasis
