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. 2021 May 4;12(1):1445–1456. doi: 10.1080/21655979.2021.1905247

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — MiR-138-5p is the target of MCM3AP-AS1. (a) StarBase database showed that miR-138-5p may be a potential target for MCM3AP-AS1. (b) Dual-luciferase reporter gene assay depicted that miR-138-5p mimics can significantly reduce the luciferase activity of wild-type MCM3AP-AS1 reporter, and has no effect on that of mutant MCM3AP-AS1 reporter. (c) qRT-PCR suggested that miR-138-5p was up-regulated in the cartilage tissues of OA patients. (d) qRT-PCR indicated that IL-1β treatment induced miR-138-5p expression in chondrocytes. (e) qRT-PCR data indicated that MCM3AP-AS1 and miR-138-5p expression levels were negatively correlated in the cartilage tissues of OA patients. (f) MiR-138-5p expression in the chondrocytes of MCM3AP-AS1 overexpression group were significantly reduced. ns.: not statistically significant

**P < 0.01, and ***P < 0.001 compared with the control.