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. 2021 May 4;12(1):1445–1456. doi: 10.1080/21655979.2021.1905247

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — MiR-138-5P reverses the role of MCM3AP-AS1 in OA chondrocytes. (a, b) CCK-8 assay results showed that the effect of MCM3AP-AS1 overexpression on cell proliferation could be offset by miR-138-5 mimics. (c) Transwell assay indicated that the effect of MCM3AP-AS1 overexpression on the migration of chondrocytes could be counteracted by miR-138-5p (d) Flow cytometry showed that the decrease in apoptosis rate induced by overexpression of MCM3AP-AS1 can be offset by miR-138-5 mimics. (E, F, G, H) ELISA results showed that the contents of inflammatory cytokines after cotransfection of miR-145-5p was significantly higher than those in MCM3AP-AS1 overexpression group

*P < 0.05, **P < 0.01, and ***P < 0.001.