Figure 6.

hsa_circ_0059930/hsa-miR-382-5p/TOP1 might be the potential regulatory axis in LPS-induced ALI. (a) Based on the circRNA and mRNA sequencing results, the related network of hsa_circ_0059930 was analyzed. (b) Through bioinformatics analysis, we predicted and displayed the potential binding sites between hsa-miR-382-5p and hsa_circ_0059930 or between hsa-miR-382-5p and TOP1. (c) qRT-PCR assay was employed for the silence identification of hsa_circ_0059930 in MRC-5 cells, *P < 0.05. (d) qRT-PCR analysis was also applied to assess the influence of hsa_circ_0059930 interference on the TOP1 expression in LPS-induced MRC-5 cells, **P < 0.01