Figure 3.

The main mechanism of BFT carcinogenesis. BFT up-regulates the expression level of SMOX and increases the synthesis of SMO, which promotes the conversion of spermine, which produces hydrogen peroxide causing DNA damage and apoptosis, and promotes the progression of cancer. BFT can induce cleavage of E-cadherin, trigger activation of Wnt by β-catenin nuclear localization, induce transcription and translation of c-Myc, and promote proliferation of CEC. BFT activates Stat3 to regulate Th17 cells, produce IL-17, and promote tumor development