TABLE 2.

Adjusted hazards of 1-y patient death in each DRI category according to eras (ref: Era 1 [2002–2007])

	Era 2 (2008–2013)		Era 3 (2014–2019)
	aHR (95% CI)	P	aHR (95% CI)	P
Overall ACLF
Overall	0.69 (0.61-0.78)	<0.001	0.48 (0.42-0.55)	<0.001
0 < DRI ≦ 1.2	0.90 (0.60-1.36)	0.623	0.60 (0.39-0.94)	0.025
1.2 < DRI ≦ 1.6	0.64 (0.53-0.76)	<0.001	0.39 (0.32-0.48)	<0.001
1.6 < DRI ≦ 2.0	0.92 (0.72-1.17)	0.483	0.70 (0.54-0.90)	0.005
2.0 < DRI	0.68 (0.49-0.94)	0.019	0.61 (0.43-0.87)	0.006
ACLF-1 and 2
Overall	0.66 (0.57-0.77)	<0.001	0.52 (0.44-0.62)	<0.001
0 < DRI ≦ 1.2	0.73 (0.43-1.23)	0.236	0.66 (0.39-1.14)	0.137
1.2 < DRI ≦ 1.6	0.70 (0.55-0.90)	0.005	0.47 (0.36-0.63)	<0.001
1.6 < DRI ≦ 2.0	0.91 (0.66-1.26)	0.572	0.80 (0.58-1.12)	0.197
2.0 < DRI	0.62 (0.42-0.92)	0.016	0.51 (0.33-0.78)	0.002
ACLF-3
Overall	0.74 (0.61-0.89)	0.001	0.43 (0.35-0.53)	<0.001
0 < DRI ≦ 1.2	1.52 (0.75-3.07)	0.244	0.59 (0.27-1.31)	0.194
1.2 < DRI ≦ 1.6	0.56 (0.42-0.73)	<0.001	0.31 (0.23-0.43)	<0.001
1.6 < DRI ≦ 2.0	0.95 (0.66-1.36)	0.786	0.59 (0.40-0.87)	0.008
2.0 < DRI	0.98 (0.52-1.85)	0.955	0.86 (0.45-1.66)	0.648
Non-ACLF
Overall	0.69 (0.64-0.75)	<0.001	0.47 (0.43-0.52)	<0.001
0 < DRI ≦ 1.2	0.90 (0.66-1.22)	0.490	0.66 (0.48-0.92)	0.013
1.2 < DRI ≦ 1.6	0.71 (0.62-0.81)	<0.001	0.47 (0.40-0.55)	<0.001
1.6 < DRI ≦ 2.0	0.71 (0.62-0.83)	<0.001	0.51 (0.44-0.61)	<0.001
2.0 < DRI	0.68 (0.57-0.82)	<0.001	0.44 (0.36-0.54)	<0.001

Bold type indicates statistically significant differences.

ACLF, acute-on-chronic liver failure; aHR, adjusted hazard ratio; CI, confidence interval; DRI, donor risk index.