TABLE 3.
Multivariable analysis of donor risk factors for 1-y patient death in ACLF patients
| Overall(2002–2019) | Era 1(2002–2007) | Era 2(2008–2013) | Era 3(2014–2019) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| aHR (95% CI) | P | aHR (95% CI) | P | aHR (95% CI) | P | aHR (95% CI) | P | ||
| Age (y) | ≤40 | Ref | Ref | Ref | Ref | ||||
| 41–50 | 1.15 (1.00-1.33) | 0.050 | 1.16 (0.88-1.52) | 0.304 | 1.09 (0.87-1.36) | 0.445 | 1.18 (0.92-1.51) | 0.191 | |
| 51–60 | 1.22 (1.06-1.41) | 0.007 | 1.07 (0.80-1.44) | 0.654 | 1.22 (0.97-1.53) | 0.086 | 1.30 (1.01-1.67) | 0.042 | |
| 61–70 | 1.57 (1.31-1.88) | <0.001 | 1.43 (1.02-2.02) | 0.041 | 1.45 (1.09-1.91) | 0.010 | 1.76 (1.28-2.44) | 0.001 | |
| 70< | 2.03 (1.51-2.75) | <0.001 | 1.50 (0.91-2.46) | 0.112 | 1.85 (1.12-3.06) | 0.017 | 2.70 (1.48-4.91) | 0.001 | |
| Gender | Male | Ref | Ref | Ref | Ref | ||||
| Female | 1.04 (0.93-1.15) | 0.502 | 0.83 (0.67-1.02) | 0.075 | 1.08 (0.92-1.27) | 0.360 | 1.15 (0.96-1.38) | 0.141 | |
| BMI (kg/m2) | <18.5 | 0.77 (0.53-1.10) | 0.149 | 1.07 (0.59-1.94) | 0.825 | 0.56 (0.30-1.06) | 0.076 | 0.77 (0.39-1.50) | 0.435 |
| 18.5–24.9 | Ref | Ref | Ref | Ref | |||||
| 25.0–29.0 | 0.90 (0.80-1.02) | 0.087 | 0.81 (0.64-1.02) | 0.070 | 0.92 (0.76-1.10) | 0.346 | 1.01 (0.82-1.25) | 0.919 | |
| ≥30 | 0.88 (0.77-0.99) | 0.042 | 0.97 (0.75-1.24) | 0.786 | 0.84 (0.69-1.03) | 0.099 | 0.92 (0.73-1.15) | 0.440 | |
| Ethnicity | White | Ref | Ref | Ref | Ref | ||||
| Black | 1.08 (0.94-1.25) | 0.285 | 1.19 (0.88-1.61) | 0.249 | 0.84 (0.66-1.06) | 0.140 | 1.45 (1.15-1.82) | 0.002 | |
| Others | 1.10 (0.96-1.25) | 0.165 | 1.18 (0.92-1.51) | 0.204 | 1.15 (0.94-1.41) | 0.171 | 1.05 (0.83-1.32) | 0.702 | |
| Organ share | Local | Ref | Ref | Ref | Ref | ||||
| Regional | 0.88 (0.79-0.99) | 0.026 | 0.98 (0.77-1.24) | 0.845 | 0.90 (0.75-1.08) | 0.250 | 1.11 (0.92-1.34) | 0.279 | |
| National | 1.10 (0.83-1.46) | 0.505 | 1.08 (0.68-1.72) | 0.754 | 1.14 (0.73-1.78) | 0.566 | 1.11 (0.60-2.06) | 0.735 | |
| Donor type | DBD | Ref | Ref | Ref | Ref | ||||
| DCD | 1.77 (1.37-2.29) | <0.001 | 1.51 (0.92-2.50) | 0.105 | 1.91 (1.32-2.78) | 0.001 | 1.67 (1.01-2.78) | 0.048 | |
| CIT (h) | ≤6 | Ref | Ref | Ref | Ref | ||||
| 6–8 | 1.14 (1.01-1.28) | 0.035 | 1.13 (0.88-1.44) | 0.353 | 1.14 (0.96-1.37) | 0.145 | 1.04 (0.85-1.28) | 0.681 | |
| 8–12 | 1.39 (1.22-1.59) | <0.001 | 1.37 (1.07-1.76) | 0.012 | 1.22 (0.99-1.51) | 0.064 | 1.29 (1.01-1.65) | 0.041 | |
| >12 | 1.36 (0.98-1.88) | 0.065 | 1.45 (0.91-2.32) | 0.118 | 0.83 (0.45-1.54) | 0.560 | 1.59 (0.74-3.38) | 0.233 | |
| Cause of death | Trauma | Ref | Ref | Ref | Ref | ||||
| Anoxia | 1.08 (0.94-1.25) | 0.253 | 1.14 (0.83-1.57) | 0.430 | 1.11 (0.89-1.38) | 0.376 | 1.22 (0.97-1.53) | 0.091 | |
| CVA | 1.23 (1.07-1.41) | 0.003 | 1.39 (1.08-1.79) | 0.010 | 1.30 (1.05-1.62) | 0.016 | 1.02 (0.79-1.31) | 0.904 | |
| Graft type | Whole | Ref | Ref | Ref | Ref | ||||
| Split | 1.24 (0.70-2.20) | 0.466 | 1.18 (0.48-2.90) | 0.718 | 0.94 (0.35-2.53) | 0.896 | 1.65 (0.52-5.21) | 0.392 |
Bold type indicates statistically significant differences.
ACLF, acute-on-chronic liver failure; aHR, adjusted hazard ratio; BMI, body mass index; CI, confidence interval; CIT, cold ischemia time; CVA, cerebrovascular accident; DBD, donation after brain death; DCD, donation after circulatory death.