Figure 3.

Schematic expression of regulation by ceRNAs during asthma. Pre-miRNA is generated in the nucleus and transfer to cytoplasm via exportin5. LncRNAs (green) and circRNAs (Orange circle) can influence miRNAs (blue) through the sponge effect in the cytoplasm in asthma. As the picture shows, the overexpression of lncRNA-MEG3 could competitively sponge miR-17 in asthma to regulate the expression of RORγt and ultimately affect the balance of Treg/Th17. Overexpressed circHIPK3 could sponge miR-326 in the cytoplasm, and then promote proliferation, migration and down-regulate the apoptosis in ASMCs by acting on STIM1