Table 2.
Function of lncRNAs involved in the pathogenesis of asthma
| Name of lncRNA | MiRNA sponge | Species/ Cells | Targets | Functions | References |
|---|---|---|---|---|---|
| lncRNA MEG3 | miR-17 | Human/ CD4+ T cell | RORγt | IL-17 secretion; Treg/ Th17 balance | [78] |
| lncRNA MALAT1 | miR-155 | Human/CD4+ T cell | T-bet, GATA-3 |
Th1/ Th2 balance | [79] |
| lncRNA RMRP | miR-155 | Mice/ CD4+ T cell | CCL2 | Th1/ Th2 balance | [94] |
| lncRNA PVT1 | miR-203a | Rat/ ASMC | E2F3 | The proliferation and migration of ASMCs | [89] |
| lncRNA PTPRE-AS1 | - | Human, mice/Macrophage | PTPRE | M2 macrophage activation | [81] |
| lnc-BAZ2B | - | Human, mice/Macrophage | BAZ2B | M2 macrophage activation | [82] |
| lncRNA-AK149641 | - | Mice/Mast cell | NF-κB | The inflammatory response in mast cells | [83] |
| lncTCF7 | - | Human/ ASMC | TIMMDC1 | The proliferation and migration of ASMCs | [87] |
| lncRNA MALAT1 | miR-150 | Human/ ASMC | eIF4E | The proliferation and migration of ASMCs | [90] |
| lncRNA BCYRN1 | miR-150 | Rat/ ASMC | - | The proliferation and migration of ASMCs | [120] |
| lncRNA TUG1 | miR-590-5p | Rat/ ASMC | FGF1 | The proliferation and migration of ASMCs | [91] |
| lncRNA TUG1 | miR-181b | Rat/ ASMC | HMGB1 | The proliferation and migration of ASMCs | [95] |
| lncRNA 00882 | miR-3619-5p | Human/ fetal ASMC | β-catenin | The proliferation of ASMCs | [92] |
| lncRNA H19 | miR-21 | Human/ ASMC | PTEN | The proliferation and migration of ASMCs | [96] |
| lncRNA CASC7 | miR-21 | Human/ ASMC | PTEN | Regulating PI3K/ AKT signaling pathway; corticosteroid resistance |
[99] |