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. 2021 Aug 10;12(1):4911–4923. doi: 10.1080/21655979.2021.1959865

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Circ_0005564 silencing inhibited BMSCs osteoblast differentiation. (a) qRT-PCR results of RUNX2, OCN, and OPN mRNA expression after circ_0005564 knockdown in BMSCs after induction at indicated time-points. *p < 0.05, **p < 0.01, N = 3. (b) The protein expression of RUNX2, OPN, and OCN were significantly decreased by circ_0005564 knockdown (*p < 0.05); (c) knockdown circ_0005564 significantly reduced ALP activity in BMSCs with osteogenic differentiation induction (***p < 0.001). (d) circ_0005564 knockdown reduced ALP protein expression in BMSCs with osteogenic differentiation induction. (e) alizarin red staining showed that circ_0005564 knockdown inhibited mineralized nodules formation in BMSCs with osteogenic differentiation induction