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. 2021 Jun 11;12(1):2263–2273. doi: 10.1080/21655979.2021.1932210

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — MiR-509-3p targets Twist

(a) The putative binding site of miR-509-3p and Twist (Position 370–376 of Twist 3ʹUTR) was shown. (b) Confirmation of miR-509-3p targeting Twist by dual-luciferase reporter assay; **P < 0.01 vs. NC group. (c) Determination of miR-509-3p expression in paracancerous and hepatocellular carcinoma (HCC) tissues utilizing qRT-PCR; ***P < 0.01 vs. Normal group. (d) Evaluation of Twist protein expression in paracancerous and HCC tissues using qRT-PCR; ***P < 0.001 vs. NC mimics group. (e) Determination of Twist expression in HCC cells using qRT-PCR; *P < 0.05, **P < 0.01 and ***P < 0.001 vs. NHC group. F. qRT-PCR-based evaluation of Twist expression in HCC cells after overexpression of miR-509-3p; **P < 0.01 vs. NC mimics group. G. MiR-509-3p was of a negative relationship with Twist in HCC cells.