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. 2021 Oct 18;12(1):8157–8172. doi: 10.1080/21655979.2021.1977562

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — BMSC-EVs improve motor dysfunction and tissue damage of hindlimbs in SCI rats. (a) Motor recovery of hindlimbs of SCI rats assessed by BBB scoring at before modeling and days 1, 3, 7, 14, 21, and 28 after modeling (N = 24/12); (b) Nissl staining analysis of nerve cell injury in SCI rat spinal cord tissues on days 7 and 28 after modeling (200×); (c) HE staining analysis of SCI rat spinal cord histopathological changes on days 7 and 28 after modeling (200×); (d) RT-qPCR for expression of miR-23b in injured spinal cord tissue. n = 6. Data are expressed as mean ± standard deviation and analyzed using one-way ANOVA, with post hoc tests using Tukey’s multiple comparisons test, *p < 0.05, **p < 0.01, ##p < 0.01 (** indicates SCI group vs. sham group, ## indicates SCI+EVs group vs. SCI group)