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. 2021 Aug 8;12(1):4983–4994. doi: 10.1080/21655979.2021.1956403

Figure 1.

Figure 1.

FAC activates iron metabolism to enhance the ferroptosis of KGN cells

(a) FAC promoted cell death, iron release and ferroptosis of KGN cells. (b) Overexpressed GPX4 inhibited the ferroptosis of KGN cells. (c) FAC increased the protein expression of TFRC and decreased GPX4. (d) Tranfection efficiency of TFRC. (e) Knockdown of TFRC suppressed the ferroptosis of KGN cells. Each experiment was performed in triplicate. **P < 0.01, ***P < 0.001, *&P < 0.01.