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. 2021 Aug 8;12(1):4983–4994. doi: 10.1080/21655979.2021.1956403

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Iron uptake induced upregulation of PINK1 enhance the ferroptosis of KGN

(a) Mitochondrial depletion induced the ferroptosis of KGN cells. (b) Mitochondrial depletion suppressed the protein expression of GPX4. (c) Mitochondrial depletion inhibited the expression of PINK1. (d) Knockdown of TFRC or NAC suppressed the expression of PINK1. (e) FRC promoted mitochondrial accumulation. (f) FAC enhanced cyto C release. (g) PINK1 KO suppressed ferroptosis of KGN. Each experiment was performed in triplicate. **P < 0.01, ***P < 0.001, *^&P < 0.01.