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. 2021 Oct 27;12(1):8753–8767. doi: 10.1080/21655979.2021.1982230

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Silenced KCNQ1OT1 suppressed cell proliferation, migration and invasion in CC. (a) RT-qPCR validated interference efficacy in SiHa cells after transfection with KCNQ1OT1 knockdown lentiviral vectors. (b) CCK-8 assay examined the influence of KCNQ1OT1 silencing on CC cell proliferation. (c-d) Wound healing assay determined the influence of KCNQ1OT1 silencing on the migrative ability of CC cells. (e-f) Transwell assay detected the influence of KCNQ1OT1 silencing on the invasive ability of CC cells. (g) Western blotting analysis assessed the influence of KCNQ1OT1 silencing on the expressions of MMP2 and MMP9 in CC cells