Figure 1.

circBCL11B expression is remarkably increased in oral squamous cell carcinoma tissues and cell lines

A circBCL11B expression in 50 couples of oral squamous cell carcinoma tissues and cell lines were detected by qRT-PCR assay (p < 0.001).B Kaplan-Meier survival curve were used to evaluate overall survival time in OSCC patients with low cirCBCL11b expression (n = 25) and high cirCBCL11b expression (n = 25) (p < 0.001). C The mRNA levels of circBCL11B in a series of OSCC cell lines (Cal-27, FADU, OECM1, SAS, HSC3, SCC9) and normal oral keratinocytes (NHOK) were showed by qRT-PCR (p < 0.01). D The expression levels of BCL11 B and cirCBCL11 B in CAL-27 and SCC9 cells after RNase R treatment were measured by qRT-PCR. E Nucleoplasmic separation assay showed the cell sublocalization of circBCL11B, which was quantified by qRT-PCR (p < 0.01). Data are summary of three independent experiment.