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. 2021 Sep 21;12(1):7177–7193. doi: 10.1080/21655979.2021.1979442

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — NSD2 is a direct target of miR-1224-5p in 5-FU-resistant OSCC cells

(A) The Venn diagram showed the downstream target genes which could bind with miR-1224-5p in PITA, RNA22, miRmap, and microT databases. (B) Starbase website predicted putative-binding sites between miR-1224-5p and NSD2. (C) NSD2 expression was detected by RT-qPCR in cells transfected with miR-1224-5p mimics. (D) RIP assays were conducted to confirm miR-1224-5p and NSD2 coexisted in RNA-induced silencing complexes (RISCs). (E) Luciferase reporter assay was conducted to verify the combination between miR-1224-5p and NSD2. (F) NSD2 expression was detected in HSC-3/5-FU and HN-4/5-FU cells transfected with NC mimics, miR-1224-5p mimics, or miR-1224-5p mimics+oe-APCDD1L-AS1. **P< 0.01, ***P < 0.001.