Figure 5.

LUM silencing attenuated TNF-α-induced cellular senescence of hNPCs by inhibiting ASK1/p38 signaling pathway via inactivating FasL expression. Analysis of senescent cells (a), telomerase activity (b) and the expression of senescence markers (c) by means of β-galactosidase staining, telomerase ELISA and western blot in TNF-α-stimulated hNPCs transfected with si-NC/si-LUM-1 or co-transfected with si-LUM-1 and Oe-NC/FasL. N = 3. ***P < 0.001 vs. TNF-α+ si-NC; ^#P < 0.05, ^##P < 0.01 vs. TNF-α+ si-LUM-1+ Oe-NC; ^ΔΔΔP<0.001 vs. TNF-α+ si-LUM-1+ Oe-FasL