Figure 5.

AIM1L expression between tumor and nontumor samples in HCC patients were compared. AIM1L was significantly upregulated tumor tissues in TCGA (P < 0.0001, A), in 50 paired tumor samples from TCGA (P < 0.0001, B), in LIRI-JP project from ICGC (P < 0.0001, C) and in GEO series including GSE45436, GSE55092, GSE84402, GSE101685, GSE14323, GSE112790, and GSE121248 (all P < 0.0001, D). In a rat model naturally occurring hepatotumorigenesis induced by oxidative stress, AIM1L was significantly upregulated in liver cancer tissues compared to normal liver tissues (P < 0.01, E)